Consistently ranked as one of the top analytical divisions in the United States, number 1 in 2006, 2007 and 2008, the analytical division is recognized as a world leader in this scientific area. Following the tradition set by the late Professor Charles N. Reilley, the division extends the frontier of the field through a focus on fundamental studies related to chemical analysis and the development of innovative instrumentation. All traditional areas of research are represented, including electrochemistry, mass spectrometry, microscopy, sensors, separations and spectroscopy.
Research projects span a wide range of chemical analysis science and include, but are not limited to, biosensors, nanoscopic materials, neurochemistry, microvolume separations and analysis, protein adsorption, supercritical fluids and single-molecule analysis; for examples of currently active research projects please see the list below. The division has strong relationships with a large number of companies in the pharmaceutical, chemical and scientific instrumentation industries, which provide continued support of research fellowships and the Analytical Seminar series.
Allbritton Group
Development of new tools to monitor signaling in single cells and microfabricated systems for manipulation and analysis of cells.
Glish Group
Development of instrumentation and methods for the application of tandem mass spectrometry (MS/MS) in the areas of peptide and protein analysis.
Jorgenson Group
Development of Ultra High Pressure Liquid Chromatography instrumentation and methodology for analysis of complex biological mixtures.
Development of Liquid Chromatography - Capillary Electrophoresis instrumentation for two dimensional analysis of highly complex mixtures.
Murray Group
Design of electrochemical methods for observations in unfamiliar media, such as semi-solids, nanoparticle phases, supercritical fluids, gas-liquid interfaces
Electrochemical reactions, analytical chemistry and reactivity of molecular films on conducting surfaces.
Ramsey Group
Development of microfluidic technologies for single cell biochemical assays such as signal transduction and protein expression. Nanofluidic devices for understanding nano-confined molecular transport and single molecule structural analysis.
Schoenfisch Group
Development of biocompatible implantable sensors for in vivo monitoring.
Development of Immunoassay/Scanning Probe Microscopy(SPM) methodology for investigation of protein adsorption at molecular level.
Wightman Group
Development and application of electrochemical sensors for in vivo monitoring of brain activity.
Microscopic imaging with Electrogenerated Chemiluminescence(ECL).
Electrospray Ionization Mass Spectrometry of Intrinsically Cationized Nanoparticles, [Au144/146(SC11H22N(CH2CH3)3+)x(S(CH2)5CH3)y]x+. Christina A. Fields-Zinna, Rajesh Sardar, Christopher A. Beasley and Royce W. Murray. J. Am. Chem. Soc., 2009, 131 (44), pp 16266–16271.
Electrogenerated IrOx Nanoparticles as Dissolved Redox Catalysts for Water Oxidation. Takaaki Nakagawa, Natalie S. Bjorge and Royce W. Murray. J. Am. Chem. Soc., 2009, 131 (43), pp 15578–15579.
Voltammetric Detection of 5-Hydroxytryptamine Release in the Rat Brain. Parastoo Hashemi, Elyse C. Dankoski, Jelena Petrovic, Richard B. Keithley and R. M. Wightman. Anal. Chem., 2009, 81 (22), pp 9462–9471.
Nitric Oxide-Releasing S-Nitrosothiol-Modified Xerogels. Daniel A. Riccio, Kevin P. Dobmeier, Evan M. Hetrick, Benjamin J. Privett, Heather S. Paul, and Mark H. Schoenfisch. Biomaterials, Volume 30, Issue 27, September 2009, Pages 4494-4502.
Voltammetry and Redox Charge Storage Capacity of Ferrocene-Functionalized Silica Nanoparticles. Christopher A. Beasley and Royce W. Murray. Langmuir, 2009, 25 (17), pp 10370–10375.
Simultaneous Decoupled Detection of Dopamine and Oxygen Using Pyrolyzed Carbon Microarrays and Fast-Scan Cyclic Voltammetry. Matthew K. Zachek, Pavel Takmakov, Benjamin Moody, R. Mark Wightman, and Gregory S. McCarty. Anal. Chem., 2009, 81 (15), pp 6258–6265 .
Analytical Chemistry of Nitric Oxide. Evan M. Hetrick and Mark H. Schoenfisch. Annual Review of Analytical Chemistry, Vol. 2: 409-433, (Volume publication date July 2009) .
Efficient Electro-Oxidation of Water near Its Reversible Potential by a Mesoporous IrOx Nanoparticle Film. Takaaki Nakagawa, Christopher A. Beasley and Royce W. Murray. J. Phys. Chem. C, 2009, 113 (30), pp 12958–12961.
Enrichment and Expansion of Cells Using Antibody-Coated Micropallet Arrays. Hamed Shadpour, Christopher E. Sims, Nancy L. Allbritton. Cytometry Part A, Volume 75A Issue 7, Pages 609 - 618.
Morphological Analysis of the Antimicrobial Action of Nitric Oxide on Gram-Negative Pathogens Using Atomic Force Microscopy. Susan M. Deupree, and Mark H. Schoenfisch. Acta Biomaterialia, Volume 5, Issue 5, June 2009, Pages 1405-1415.