Our research is directed at developing new biological applications of transition-metal redox chemistry. We have worked extensively recently on studying the electrochemical properties of nucleic acids catalyzed by transition metal complexes, such as Ru(bpy)3²⁺. In this system, electrons are carried from the nucleobases (guanine and its derivatives) to electrodes by the mediator. This approach has produced technologies for detecting specific nucleic acid sequences that are being commercialized for use in pharmaceutical research by Osmetech LLC.

Our present research in this field involves understanding the electron transfer reactions of nucleic acids at highly miniaturized electrodes, developing new nucleobases that undergo facile electron transfer, performing biological assays using these approaches, and developing related reactions for detection and study of carbon nanotubes and amino acid residues in proteins.

Another area of interest in our group is the development of transition-metal mediated binding of inhibitors to serine proteases. We have recently identified imidazole compounds with extremely high affinities for pharmaceutically relevant proteases in the presence of transition metal ions.

A final project involves studying the regulation of expression of genes that transport and store iron in cells. The translation of many of these proteins is regulated by a structure in the mRNA called the iron responsive element. We have identified small molecules that bind to this mRNA and modulate iron transport and storage. These molecules will be useful for treatment of sickle cell disease and iron overload.

As of July 1st, 2007, Professor Thorp is the Dean of the College of Arts & Sciences at UNC

Prof. Thorp delivered the December 2006 commencement address.

Prof. Thorp also writes a regular column on the relationship of science to other fields for the Wake County Physician. To read Dr. Thorp’s columns, click on the image below: