Synthetic Organic Chemistry, Asymmetric Catalysis
B.S., University of Kansas (1994); Ph.D., Harvard University (1999); NIH Postdoctoral Fellow, University of California, Berkeley (1999-2001);Research Corporation Research Innovation Award (2002); National Science Foundation CAREER Award (2003-2008); 3M Nontenured Faculty Award (2003); UNC Junior Faculty Development Award (2004); Johnson and Johnson Focused Giving Award (2004-2006), Eli Lilly Grantee (2004), Amgen Young Investigator Award (2005), GSK Scholar Award (2006-2007); Alfred P. Sloan Fellow (2006-2008); Camille Dreyfus Teacher Scholar (2006-2009); Ruth and Phillip Hettleman Prize for Artistic and Scholarly Achievement (2006); Novartis Early Career Award in Organic Chemistry (2008); American Chemical Society's Arthur C. Cope Scholar Award in Recognition of Excellence in Organic Chemistry (2010); Elias J. Corey Award (2012)
My interests lie in the general area of chemical synthesis. I am particularly interested in the discovery of new organic transformations and their application to the total synthesis of architecturally challenging and biologically important natural products. Our criteria for the development of a synthetic method may be summarized by three characteristics:
The reaction should achieve several structural modifications in a single synthetic operation: tandem or domino reactions are optimal;
The reaction should introduce a significant level of stereochemical complexity in a controlled fashion and absolute stereocontrol should arise from a chiral source used in catalytic quantities;
The starting materials should be readily accessed, but be easily transformed into complex products. To meet these challenges, students in my group will learn a full complement of organic and organometallic chemistry.