Department of Chemistry
Dorothy Erie

Dorothy Erie

Professor
derie@email.unc.edu
919-962-6370
919-962-2388 (fax)
GSB 4360

 

Research Interests

Scanning Force Microscopy, Biological Chemistry

Professional Background

Ph.D., Rutgers-The State University of New Jersey (1989); M.S. University of Wisconsin (1985); B.S. Louisiana State University (1982)

Research Synopsis

The research in my lab is divided into two main areas:

1) Atomic force microscopy and fluorescence studies of protein-protein and protein-nucleic acid interactions, and

2) Mechanistic studies of transcription elongation. My research spans the biochemical, biophysical, and analytical regimes.

Listed below is an outline of research topics. More detailed information about each topic is included in the Research Projects page and on my group page.

Atomic Force Microscopy
Studies of the structure-function relationship of protein-protein and protein-DNA interactions related to DNA repair

Fluorescence Spectroscopy
Development of a combined AFM-fluorescence microscope for the study of multi-protein systems
Single-molecule fluorescence spectroscopy of protein-DNA complexes
Transcription Elongation

Transient-state kinetic studies of single and multiple nucleotide incorporation
Characterization of RNA polymerases from thermophilic bacteria

 

Collaborators

Russel M. Taylor II, Richard Superfine