The Jeff Johnson Group focuses on the development of new synthetic methods for the assembly of stereochemically complex small molecules. We are particularly interested in the design and synthesis of tailor-made reagents and catalysts for multicomponent reactions. In our recent investigations of several interesting problems, our continuing interest in the exploitation of ring strain as a source of novel reactivity led us to some mechanistically unusual heterocycle-forming cycloadditions of cyclopropanes and aldehydes. On another front, we are interested in the development of dipolar synthons for the coupling of complementary nucleophilic and electrophilic reaction partners. Our development of silyl glyoxylate reagents is an example of work in this area.
The Jorgenson Group is taking high pressure separations to a new level with the analysis of complex mixtures. Current projects in the group focus on identifying differential proteins in yeast cell lysates, separations of intact monoclonal antibodies, and analysis of membrane proteins. The group recently attended the 32nd Int'l Symposium on Capillary Chromatography in Riva del Garda, Italy where Brenna McJury was awarded the third place Pfizer Analytical Research Centre 2008 Best Contribution Award for her poster on two-dimensional differential chromatography.
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