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The Gagné Group

The Gagné Group

The Gagné Lab is interested in the development of new synthetic methods for complex bond constructions. To mimic sterol biosynthesis, we have developed several "carbophilic" late metal catalysts (Pd, Pt, and Au) for alkene and allene activation, while in other projects we seek new catalysts for glycosidic C-O bond activation. The goal in this latter project is to use polysaccharides as renewable feedstocks for complex molecule synthesis. A third major thrust is in dynamic combinatorial chemistry (DCC), a dynamic templating strategy that selects for new receptors under competitive binding conditions. This strategy is additionally being used for new catalyst discovery.

 

The Erie Group

The Erie Group

Members of the Erie Group focus on using single molecule and biochemical methods to better understand the kinetics and thermodynamics of protein-nucleic acid interactions. Current single molecule techniques used in the lab include Atomic Force Microscopy (AFM) and Total Internal Reflection Microscopy (TIRM) techniques such as Fluorescence Resonance Energy Transfer (FRET). A major focus of our lab is the characterization of both the static and the dynamic protein-nucleic acid interactions that govern the overall repair specificity of mismatched or damaged DNA in prokaryotic and eukaryotic organisms. A few questions we are addressing include the following: How is mismatch repair initiated on some mismatches but not others? What properties of a damaged DNA substrate initiate apoptosis over mismatch repair? What roles do the mismatch repair initiation proteins, MutS and MutL, play in that separation of pathways? What are the structures/conformations of the multi protein-DNA complexes that control DNA repair? We are also characterizing a host of other protein-DNA interactions involved in DNA repair. There are projects within the group that would appeal to most areas of interest. Our group is composed of students from a variety of backgrounds and departments including chemistry, materials science, physics, and biophysics.

 

Contact Information

AREA CONTACT PHONE
Administration Ruth Hyde 919-962-2173
Accounting & Sponsored Research Karen Holmes 919-962-1189
Human Resources Nancy Ray 919-962-2174
Karen Gilliam 919-843-3452
Student Services Graduate Inquiries 919-843-7827
Undergraduate Inquiries 919-843-7826
Technical Support & Facilities Peter White 919-962-1689
Technology Development/Industry Liason Joonhyung Cho 919-843-3165
Undergraduate Laboratories Nita Eskew 919-962-4796
Mathew Steadman 919-843-7218
Kathleen Coughlin 919-962-5571
Web Content & Information Management Lars Sahl 919-962-6193
General Inquiries   919-843-7100
Fax   919-962-2388

 

Department Mailing Address

Department of Chemistry
Campus Box 3290
Caudill and Kenan Laboratories
The University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-3290

 

Department Shipping Addresses

Kenan Laboratories, Room#
Department of Chemistry
125 South Road
The University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-3290

 

Caudill Laboratories, Room#
Department of Chemistry
131 South Road
The University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-3290

 

Venable Hall or Murray Hall, Room#
Department of Chemistry
123 South Road
The University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-3290

 

Chapman Hall, Room#
Department of Chemistry
205 S Columbia St
The University of North Carolina at Chapel Hill
Chapel Hill, NC 27599-3290

 

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