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The Wightman Group

Research in the Wightman Group is directed at the development of microsensors and their use to measure chemical events in microenvironments. We have developed ultramicroelectrodes that are robust chemical sensors, which can resolve chemical events with micron or submicron spatial resolution. In addition, these probes can be used for measurements on the nanosecond time scale and in environments in which electrochemical measurements are normally impossible.

The Weeks Group

The Weeks laboratory is inventing high-throughput technologies for analyzing the structure of RNA. In one recent result, the lab has reported the architecture and secondary structure of an entire HIV genome. Ongoing work focuses on creating new RNA chemistries, on drug discovery, and on analyzing RNA structure-function relationships inside viruses and cells.