The Crimmins Group focuses on new methods development for the stereoselective construction of complex biologically active natural products. Most specifically, titanium enolates of acyloxazolidinethiones and acylthiazolidinethiones can be utilized in the enantio- and diastereoselective formation of beta-hydroxy acid derivatives and alpha, beta-hydroxy acid derivatives through chiral auxiliary-controlled aldol additions. All possible diastereomers can be accessed through slight modifications of reaction conditions. Incorporation of a terminal alkene into the aldehyde and acyloxazolidinethione allows for the ultimate construction of medium ring ethers by means of ring-closing metathesis. Utilization of this strategy recently culminated in the enantioselective synthesis of the complex ladder toxin Brevetoxin A.
The research in the Rubinstein Group is in the field of polymer theory and computer simulations. The unique properties of polymeric systems are due to the size, topology and interactions of the molecules they are made of. Our goal is to understand the properties of various polymeric systems and to design new systems with even more interesting and useful properties. Our approach is based upon building and solving simple molecular models of different polymeric systems. The models we develop are simple enough to be solved either analytically or numerically, but contain the main features leading to unique properties of real polymers. Computer simulations of our models serve as an important bridge between analytical calculations and experiments.
Apart from all the work happening inside the structure, such as with ductwork, electrical, stairs, air handling equipment, and the million valves and pipes that fill the space above the future ceilings, the brickworkers on the outside of the building are quickly climbing up the facade, one row of bricks at a time. The masonry work on both East and West walls are now virtually complete.
These images were taken on August 19th. Roof covering is laid down, and windows are being put in. The connection between Caudill Labs and the new building is now covered and glassed. Next, openings will be made in the walls on the Caudill side to truly connect the new building as shown below. Both external and internal work plans are progressing on schedule.
Connecting walkway from "New Venable" to Caudill Labs
The Science Complex Courtyard with Kenan Labs in the background
External view of the connecting walkway from "New Venable" to Caudill Labs
Miles and miles of wires and pipes...
Future classrooms are beginning to take shape.
The above images chronologically depict the demolition of Venable Hall, followed by the site-preparation for and the construction of the Physical Sciences Building.
Follow the progress at the new Venable Hall construction site with our live webcam. The camera is located on the observation deck on top of Chapman Hall.
Although Old Venable Hall has been reduced to rubble, you still have an opportunity to retain a piece of the past, touch your memories and support Carolina Chemistry and the construction of New Venable Hall. We rescued a limited number of bricks from the east facade of Old Venable hall. Scrubbed meticulously clean and prepared to exacting standards by Alpha Chi Sigma volunteers, these rare artifacts are being offered to Venable alumni either as Chancellor's Edition Bricks, only 25 to be offered, Limited Edition Brick, only 250 to be offered, or as the Venable Brick Slice paper weight. Thank you for your continued support of UNC Chemistry.
To Donate to Chemistry and receive your Venable Hall memorabilia:
For additional information, please call 919-962-6193