The Lockett Group uses a multidisciplinary approach, combining aspects of analytical chemistry, materials science, biochemistry, molecular biology, and biomedical engineering to develop new analytical tools and in vitro assays to predict and quantify molecular interactions occurring in a cell or within a community of cells.
We are particularly interested in developing new technologies to: i) fabricate arrays of biomolecules in which we could screen drug metabolism in a high-throughput manner; ii) study the response of enzymes and cells to environmental stresses in tissue-like constructs that mimic in vivo conditions. We focus keenly on analytical tools that are amenable to high-throughput screening, are easily assembled or setup, and provide quantitative data.
The research in the Rubinstein Group is in the field of polymer theory and computer simulations. The unique properties of polymeric systems are due to the size, topology and interactions of the molecules they are made of. Our goal is to understand the properties of various polymeric systems and to design new systems with even more interesting and useful properties. Our approach is based upon building and solving simple molecular models of different polymeric systems. The models we develop are simple enough to be solved either analytically or numerically, but contain the main features leading to unique properties of real polymers. Computer simulations of our models serve as an important bridge between analytical calculations and experiments.
Chancellor's Eminent Professor of Chemistry, Joseph DeSimone, has been elected to the Institute of Medicine, one of the highest honors in the fields of health and medicine a U. S. scientist can receive. His election to Institute of Medicine represents the third time he has been named a member of a U. S. National Academy. He was elected to the National Academy of Engineering in 2005 and the National Academy of Sciences in 2012. Fewer than 20 people in history have achieved election to all three U. S. National Academies, and he is the first individual in the state of North Carolina to be named to all three U. S. National Academies.
"DeSimone is a renaissance scientist," said Chancellor Carol L. Folt. "He was the first to successfully adapt manufacturing techniques from the computer industry to make advances in medicine, including next-generation approaches to cancer treatment and diagnosis. He provides a beautiful example of how transcending disciplines can revolutionize science and open up entirely new fields of study. We are very proud of what Professor DeSimone and his students have accomplished. He is a gifted and talented teacher and amazing University citizen."
As announced by Israeli Prime Minister Benjamin Netanyahu on October 6th, Arey Distinguished Professor of Chemistry, Thomas Meyer, is one of two winners of the 2014 Eric and Sheila Samson Prime Minister's Prize for Innovation in Alternative Fuels for Transportation. Professor Meyer is recognized as a world leader in solar fuel research.
The $1 million prize is awarded for breakthrough work into converting solar energy into electricity capable of powering transportation. "We are making a major multi-year effort so that we will not be dependent on fluctuations in the price of oil," Netanyahu said. "This prize gives the researchers true appreciation for their efforts." The Eric and Sheila Samson Prize, totaling $1 million, is the world’s largest monetary prize awarded in the field of alternative fuels, and is granted to scientists who have made critical advancements."
Congratulations to Dr. Meyer on receiving such a prestigious international honor," said UNC Chancellor Carol L. Folt. "Dr. Meyer is a superb example of the kind of innovation we champion here at UNC, using research to solve the world's most pressing problems. By pairing a basic scientific knowledge of photosynthesis with the latest advances in nanotechnology, Dr. Meyer and his team are bringing the world closer than ever to making solar energy a practical, reliable power source."
Assistant Professor Leslie Hicks has been awarded the Arthur C. Neish Young Investigator Award. These awards are given each year by the Phytochemical Society of North America to outstanding early career scientists. The young investigator chosen will present their research at the annual meeting as part of the Arthur C. Neish Young Investigator Mini-symposium. Leslie made her presentation earlier this month at the 53rd Annual Meeting in Raleigh. Congratulations, Leslie!
We congratulate Assistant Professor James Cahoon as being one of eighteen national recipients of a David and Lucile Packard Foundation Fellowship. James was elected as one of the nation's most innovative early-career scientists and engineers receiving a 2014 Packard Fellowships for Science and Engineering. Each Fellow will receive a grant of $875,000 over five years to pursue their research.
"The Packard Fellowships are an investment in an elite group of scientists and engineers who have demonstrated vision for the future of their fields and for the betterment of our society," said Lynn Orr, Keleen and Carlton Beal Professor at Stanford University, and Chairman of the Packard Fellowships Advisory Panel. "Through the Fellowships program, we are able to provide these talented individuals with the tools and resources they need to take risks, explore new frontiers and follow uncharted paths."
Lowering the modulus of hydrogel particles could enable them to bypass in vivo physical barriers that would otherwise filter particles with similar size but higher modulus. Incorporation of electrolyte moieties into the polymer network of hydrogel particles to increase the swelling ratio is a straightforward and quite efficient way to decrease the modulus. In addition, charged groups in hydrogel particles can also help secure cargoes. However, the distribution of charged groups on the surface of a particle can accelerate the clearance of particles.
Published in JACS, researchers in the DeSimone Group have developed a method to synthesize highly swollen microgels of precise size with near-neutral surface charge while retaining interior charged groups. A strategy was employed to enable a particle to be highly cross-linked with very small mesh size, and subsequently PEGylated to quench the exterior amines only without affecting the internal amines. Acidic degradation of the cross-linker allows for swelling of the particles to microgels with a desired size and deformability. The microgels fabricated demonstrated extended circulation in vivo compared to their counterparts with a charged surface, and could potentially be utilized in in vivo applications including as oxygen carriers or nucleic acid scavengers.
Caitlin McMahon, a fourth year graduate student in the Alexanian Group, has been selected by the ACS Division of Organic Chemistry to receive a 2014-2015 Graduate Fellowship. Awardees for this highly competitive award are selected by an independent committee, and evidence of research accomplishments is an important factor in the selection process. Caitlin will travel to the 2015 National Organic Symposium to present a poster of her research.
Caitlin's research focuses on the development of metal-catalyzed organic reactions, with the goal of discovering new ways to form carbon-carbon bonds and expanding the methodology available to synthesize organic building blocks. More specifically, she has developed a palladium-catalyzed, intermolecular Heck-type reaction using alkyl electrophiles - significantly expanding the scope of the widely-utilized Heck reaction. She is currently studying carbonylative metal-catalyzed reactions, building functionalized organic molecules by forming two carbon-carbon bonds in one step under mild conditions.
At the Department of Chemistry, we feel strongly that diversity is crucial to our pursuit of academic excellence, and we are deeply committed to creating a diverse and inclusive community. We support UNC's policy, which states that "the University of North Carolina at Chapel Hill is committed to equality of opportunity and pledges that it will not practice or permit discrimination in employment on the basis of race, color, gender, national origin, age, religion, creed, disability, veteran's status, sexual orientation, gender identity or gender expression."